Plasma amino acids

Definition

Plasma amino acids is a screening test done on infants that looks at the amounts of amino acids in the blood. Amino acids are the building blocks for proteins in the body.

See also:

Alternative Names

Amino acids blood test

How the Test is Performed

A blood sample is needed. The area (usually the heel) is cleansed with germ-killing solution, and the skin is punctured with a sharp needle or a lancet. The blood collects into a small glass tube called a pipette, or onto a slide or test strip. A bandage may be placed over the area if there is any bleeding.

The blood sample is sent to a lab. Chromatography is used to determine the amino acids levels in the blood.

How to Prepare for the Test

The baby should not be fed for 4 hours before the test.

See also: Test/procedure preparation - infant

How the Test Will Feel

The needle stick will probably cause the infant to cry.

When the needle is inserted to draw blood, some people feel moderate pain, while others feel only a prick or stinging sensation. Afterward, there may be some throbbing.

Why the Test is Performed

This test is done to measure the level of amino acids in the blood.

An increased level of a particular amino acid is a strong sign that there is a problem with the body's ability to break down (metabolize) that amino acid.

The test may also be used to look for decreased levels of amino acids in the blood, which may occur with fevers, inadequate nutrition, and certain medical conditions.

Normal Results

All measurements are in micromole per liter (micro mol/L). Normal values may vary between different laboratories. Talk to your doctor about your specific test results.

The examples above show the common measurements for results for these tests. Some laboratories use different measurements or may test different specimens.

What Abnormal Results Mean

An increase in the total level of amino acids in the blood amino may be due to:

A decrease in the total level of amino acids in the blood may be due to:

High or low concentrations of individual plasma amino acids must be interpreted along with other clinical information. Abnormal results may be due to diet, hereditary problems with the ability of the body to handle the amino acid, or to drug effects.

Risks

Risks associated with having blood drawn are slight:

Considerations

Screening infants for increased levels of amino acids can lead to early diagnosis of inborn errors of metabolism. Early treatment for such conditions may prevent complications such as severe mental retardation.

Review Date: 5/12/2011
Reviewed By: Frank A. Greco, M.D., Ph.D., Director, Biophysical Laboratory, The Lahey Clinic, Burlington, MA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
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